1-39-Corticotropin (human)(TFA)
CAS No.
1-39-Corticotropin (human)(TFA) ( Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) )
Catalog No. M29941 CAS No.
Adrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product Name1-39-Corticotropin (human)(TFA)
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NoteResearch use only, not for human use.
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Brief DescriptionAdrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells.
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DescriptionAdrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells.(In Vitro):Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH 1-39), a member of the melanocortin family, stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells. ACTH 1-39 protects neurons in vitro from several apoptotic, excitotoxic and inflammation-related insults. The conditioned medium (CM) is prepared from untreated astroglia (AS) cultures and from AS cultures treated with 200 nM ACTH 1-39 for 24 h, washed to remove ACTH 1-39, then incubated for another 24 h in DMEM. In initial experiments, no difference is found in oligodendroglia (OL) viability in the presence of OL definedmediumwith 2% newborn calf serum (NCS) or AS CM (prepared in DMEM with no serum). After 24 h, OL death under each condition varies between 1 and 4%. Similar results for OL viability are obtained with microglia (MG) CM. In subsequent experiments, controls in each experiment consist of OL in defined medium with 2% NCS.
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SynonymsAdrenocorticotropic Hormone (ACTH) (1-39), human(TFA)
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight4655.2
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Molecular FormulaC207H308N56O58S.C2HF3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7.
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